Collagen peptides include highly functional products that have been confirmed to inhibit alkaline phosphatase (ALP) activity, which promotes joint calcification.

PATENTED

The WOMAC score is a worldwide disease-specific measure for health-related quality of life in osteoarthritis. The intake of Collapep JB improved significantly.

The VAS score gives an indication of the patient's own pain. The results showed that patients experienced a reduction in pain.

The X-ray images show less pointy bone shape, allowing for joint space generation.

Reference：Kumar et al., J Sci. Food Agric., 95_2014

Mean, Tukey test was performed as a post-hoc test for one-way ANOVA.

### p < 0.001, VS Placebo, Paired Tukey test, *** p <0.001, VS Baseline

WOMAC = Western Ontario McMaster Universities Arthritis Index

CTX-II= C-terminal telopeptides of collagen type II

MOAK = Magnetic Resonance Imaging Osteoarthritis Knee Score

QoL = Quality of Life

Reduction(%)= (Day 90 – Baseline) / Baseline ×100

Reference：Devasia S, Joseph JT, P.S. S, et al. Management and Amelioration of Knee Joint Osteoarthritis in Adults Using a Novel High-Functional Bovine Collagen Peptide as a Nutritional Therapy: A Double-Blind, Prospective, Multicentric, Randomized, Active and Placebo Controlled, Five-Arm, Clinical Study to Evaluate the Efficacy, Safety, and Tolerability. CARTILAGE. 2024;0(0). doi:10.1177/19476035231221211

The DI-PEPTIDE group had better results than the placebo group in the WOMAC score, CTX-II level, a marker for the degradation of type II collagen in the joint, and MOAK as MRI imaging joint evaluation. Thus, the patients' QOL score improved significantly from the 30th day. Furthermore, DI-PEPTIDE results showed the almost the same with standard type collagen peptide to those obtained with a 10g intake. It represents DI-PEPTIDE can reduce the intake volume in joints management. It is believed that the active ingredients PO and OG inhibit alkaline phosphatase activity in the joints, thereby inhibiting calcification (ossification) of the joints.

Mean ± SE,  ＊ VS Placebo, # VS Baseline

Running club students who had a heavy load on their knee joints due to training consumed 5 g of collagen peptide daily, and a significant improvement in their JKOM score (knee condition in daily life) was confirmed compared to the placebo group.
The blood level of 3-methylhistidine, a muscle degradation marker, was significantly increased in the placebo group 4 weeks after the ingestion, whereas it was not changed in the collagen peptide group. It was suggested that the intake of collagen peptide may have suppressed muscle degradation.

Reference：Kimira Y, Saito M, Kushibe S, Nomura K, Osawa Y, Sekiguchi Y, Shimizu J, Nakatani S, Koizumi S, Inoue N, Mori Y, Kobayashi J, Mano H,The effects of collagen peptide supplementation on knee joint health - a doble-blind, placebo-controlled, randomized trial in healthy university students belonging to a running club-. Japanese pharmacology and Therapeutics, 47(9), 1455-1462, 2019