| 4-4. | Mechanism |
Pro-Hyp (PO) and Hyp-Gly (OG) concentrations elevate in the wound site, promoting MMP9 production. MMP9 is an enzyme that breaks down damaged collagen and promotes skin remodeling.
Pro-Hyp and Hyp-Gly promotes the migration and proliferation of skin cells, closing the wound site.
Stimulating the synthesis of new collagen in the dermis, it restores to the original amount of collagen. Pro-Hyp also promotes hyaluronic acid synthesis.
| 4-5. | Animal Studies |
| ● | Wistar rats, after pressure ulcer creation by biopsy |
| ● | Casein group : feed with 15% casein |
| Collagen peptide group : feed with 10% casein and 5% collagen peptide | |
| ● | Evaluation : wound area, new collagen amount, MMP-9 |
The wound area was significantly reduced in collagen peptide group compared to the casein group, and the amount of newly produced collagen recovered from 1 day after wound formation until there was no significant difference from the normal time. In the collagen peptide group, MMP9, which plays a role of cleaning wounds, was distributed mainly in the basement membrane, whereas in the casein group, MMP9 was scattered and showed chronic inflammation.
Reference: Horiuchi et al, 4th conference of Japanese Society for Amino Acid Sciences
