It was found that the addition of DI-PEPTIDE enhances the expression of genes such as keratin 10, involucrin and transglutaminase, which are indicators of epidermal turnover, and promotes turnover.

Gene expression measured by RT-PCR using normal epidermal keratinocytes

Mean±SE, Tukey test, **p<0.01 (vs Blank)

Reference：Research results by Nitta Gelatin Inc.

• Elimination of active oxygen species
• Inhibition of melanin synthesis factors (ET-1, DCT)
• Promotion of turnover of epidermis, resulting in quick elimination of melanin pigments

• Enhancing gene expression of HAS2, AQP3, FLG at epidermal keratinocytes
• Enhancing gene expression of the factors for epidermal barrier functions (K10,Ivl,TG,FLG,TJAP,SPTLC1)
• Promotes synthesis of collagen and hyaluronic acid in dermal fibroblasts

• Promotes elastin gene expression
• Relieves UV damage

PATENTED

In the Highly functional type collagen peptide group, the wrinkles of the epidermis were remarkably suppressed, and the thickening of the epidermis due to UV was suppressed. Furthermore, it was also shown that wrinkle formation was significantly suppressed, moisturizing properties and skin redness were significantly reduced in Highly functional type collagen peptide group compared to the UV irradiation group.

UVB: Ultraviolet B wave, CP: Collagen peptide

UVB: Ultraviolet B wave, CP: Collagen peptide

UVB: Ultraviolet B wave, CP: Collagen peptide

Ingested collagen peptide in 6-week-old hairless mice at 5 g/day or 10 g/day for 12 weeks (human equivalent of 60 kg body weight).
UVB irradiation was performed 3 times / week for a total of 8100 mJ / cm~{2}.
Mean±SD, ###p<0.001, ##p<0.01, #p<0.05 (vs normal), **p<0.01, *p<0.05 (vs UVB)

Reference：Hyun-Jun Shin, Jong ilPark, Chang-Ju Kwon, Hwa young Kim, Inoue N, Koizumi S, Jae Sung Hwang; The Effect of Collagen Peptide Intake on UVB-induced Skin Damage in Hairless mice. Journal of the Korea Academia-Industrial cooperation Society;17 (3) , 611-621, 2016