A clinical trial paper on the effects of collagen hydrolysates derived from Tilapia scales or skin on human facial skin was published in Japanese Pharmacology and Therapeutics volume 47, no.1, p57-63 (2019)

 

Background: Several human studies have demonstrated the beneficial effects of fish collagen hydrolysates (CHs) on facial skin parameters, including skin moisture, elasticity, and roughness. However, no clinical reports have assessed CHs derived from different parts of the same organism. Thus, the present clinical study assessed the effects of CHs derived from fish scales and those derived from fish skin on human facial skin.

 

Methods: The present randomized double-blind placebo-controlled clinical study evaluated 82 subjects. These subjects received CHs derived from Tilapia scales (CH-A group; n = 28), CHs derived from Tilapia skin (CH-B group; n = 28), or maltodextrin (placebo group; n = 26). Skin parameters, such as skin moisture, elasticity, wrinkles, and roughness, were compared among the groups at the baseline, and 4 and 8 weeks after starting daily intake of CHs or placebo. Additionally, the safety of CH administration was evaluated.

 

Results: Significant improvements in facial skin moisture, elasticity, wrinkles, and roughness were noted in the CH-A and CH-B groups when compared with the findings in the placebo group. In addition, there were no adverse effects during the study.

 

Conclusion: CHs derived from fish scales and those derived from fish skin have similar effects on human facial skin with regard to moisture, elasticity, wrinkles, and roughness. Our findings suggest that the physiological functionality of CHs might be maintained even when they are derived from different parts of the same organism.